UpToDate This link opens in a new windowUpToDate covers more than 7,400 topics in 13 medical specialties and includes more than 76,000 pages of text, graphics, links to Medline abstracts, more than 254,000 references, and a drug database. Physician editors and authors review and update the content continuously. An updated version of UpToDate is released every four months. UpToDate is evidence-based and uses a literature-driven updating system; more than 400 journals are monitored by editors and authors, and anytime something of importance is published, it is incorporated into the program.